VIP (Vasoactive Intestinal Peptide)

VIP is a 28-amino acid neuropeptide naturally produced throughout the human body, with particularly high concentrations in the brain, gut, and respiratory system. First isolated in 1970 from pig intestines, VIP functions as both a neurotransmitter and hormone, regulating everything from circadian rhythms to immune responses [1]. The peptide's name reflects its original discovery as a potent vasodilator, though we now understand its effects extend far beyond blood vessel regulation.\n\nSynthetic VIP gained attention in integrative medicine circles primarily through the work of Dr. Ritchie Shoemaker, who developed intranasal VIP protocols for chronic inflammatory response syndrome (CIRS) — a condition he associates with biotoxin exposure, particularly from water-damaged buildings [Traditional — Shoemaker Protocol]. The peptide's anti-inflammatory and immunoregulatory properties made it an attractive intervention for patients with persistent inflammatory symptoms that didn't respond to conventional treatments.\n\nToday, people use VIP primarily as a nasal spray for various inflammatory conditions, though availability remains limited due to regulatory constraints. The peptide requires compounding pharmacy preparation and typically needs prescription access, making it less accessible than many other research compounds in this space.