MOTS-c
A mitochondrial-derived peptide that activates AMPK, the master metabolic switch. Described as an exercise mimetic — improves glucose uptake and fatty acid oxidation.
Quick Reference
- Primary effects
- Energy Boost
- Onset
- Days-weeks (cumulative)
- Duration
- Ongoing with protocol
- Intensity
- Subtle
- Legal status
- Legal (US)
- Evidence level
- Community consensus
Key Compounds
Effects
What you're here for
The Science
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Dosage
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Forms & How to Use
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Safety
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Health Disclaimer: This information is for educational purposes only and is not medical advice. Consult a qualified healthcare provider before using any substance, especially if you take medications or have a medical condition.
Legal Status
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Key Compounds
Featured In
JRE #2461 — RFK Jr. Announces FDA Peptide Reclassification
by Joe Rogan & Robert F. Kennedy Jr. · Feb 27, 2026
“MOTS-c included in the 14 peptides moving back to Category 1 compounding status.”
Sources & Citations
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