Myrcene

Myrcene is a monoterpene found abundantly throughout nature, most notably as the dominant terpene in cannabis—comprising up to 65% of total terpene content in many strains [1]. Beyond cannabis, myrcene occurs naturally in hops (contributing to beer's distinctive aroma), mangoes, lemongrass, bay leaves, and thyme. It's also present in ylang-ylang essential oil and wild thyme.

Chemically classified as an acyclic monoterpene with the molecular formula C₁₀H₁₆, myrcene serves as a precursor to other terpenes in plant biosynthesis. Its earthy, musky scent with hints of clove has made it valuable in perfumery and flavoring. What makes myrcene particularly interesting from a pharmacological perspective is its ability to enhance cellular permeability—essentially acting as a facilitator for other compounds to cross biological barriers more effectively [2].

This permeability-enhancing property explains why myrcene-dominant cannabis strains are often associated with stronger, more sedating effects. The terpene doesn't just contribute its own activity; it amplifies the absorption and distribution of cannabinoids and other plant compounds throughout the body.