Fisetin

Fisetin is a bioactive flavonoid belonging to the flavonol subclass, characterized by its unique molecular structure that makes it particularly effective at crossing the blood-brain barrier [1]. Found naturally in strawberries (which contain the highest concentrations), apples, persimmons, grapes, onions, and cucumber, fisetin stands out among flavonoids for its dual action as both a senolytic agent and neuroprotective compound [2].

Unlike many other flavonoids that primarily function as antioxidants, fisetin's mechanisms extend far beyond free radical scavenging. Its ability to selectively eliminate senescent cells—damaged cells that accumulate with age and contribute to inflammation—places it in the emerging class of senolytic compounds [3]. This positions fisetin at the intersection of longevity research and cognitive health, making it particularly relevant for age-related neurodegeneration.