THC

Delta-9-tetrahydrocannabinol (THC) is the primary psychoactive compound in *Cannabis sativa* and *Cannabis indica*, typically comprising 10-30% of dried flower depending on strain and cultivation [1]. As a terpenophenolic compound, THC belongs to the cannabinoid class of molecules that interact with the human endocannabinoid system. Unlike CBD, THC produces intoxicating effects through direct activation of cannabinoid receptors.

While cannabis remains THC's primary natural source, trace amounts occur in other plants including *Rhododendron* species and certain liverworts, though at concentrations far too low for psychoactive effects [2]. The compound exists in several isomers, but delta-9 THC represents the most abundant and pharmacologically active form found in cannabis.

THC's significance extends beyond recreational use. Its unique receptor binding profile and psychoactive properties make it distinct among cannabinoids, driving both therapeutic applications and regulatory complexity across jurisdictions. Understanding THC is essential for anyone working with cannabis-derived products, as it largely determines legal classification and user experience.